（R）－N－（γ－烃基－δ－酮己酰基）四氢噻唑－2－硫酮－4－羧酸乙酯的合成及其同（R，S）－α－苯乙胺的反应

Synthesis of (R)-N-(γ-alkyl-δ-keto-hexanoyl)thiazolidine-2-thione-4-carboxylic Ethyl Ester and Its Reaction with(R,S)-α-Phenyl Ethylamine

γ－甲基－δ－酮己酸，γ－异丙基－δ－酮己酸在碘化Ｎ－甲基－２－氯吡啶盐存在下分别同（Ｒ）－四氢噻唑－２－硫酮－４－羧酸乙酯反应，得到光学活性的（Ｒ）－Ｎ－（γ－甲基－δ－酮己酰基）四氢噻唑－２－硫酮－４－羧酸乙酯（１ａ）及光学活性的（Ｒ）－Ｎ－（γ－异丙基－δ－酮己酰基）四氢噻唑－２－硫酮－４－羧酸乙酯（１ｂ）。１ａ，１ｂ分别同（Ｒ，Ｓ）－α－苯乙胺反应得到光学活性的酰胺２ａ，２ｂ，同时使（Ｒ，Ｓ）－α－苯乙胺拆分，得到光学活性的α－苯乙胺。

Optically active(R)-N-(γ-methyl-δ-ketohexanoyl)thiazolidine-2-thione-4-carboxylic ethyl ester la and(R)-N-(γ-isopropyl-δ-ketohexanoyl)thiazolidine-2-thione-4-carboxylic ethyl ester 1b were obtianed through the reaction of γ-methyl-δ-ketocaproic acid or γ-isopropyl-δ-ketocaproic acid with(R)-thia-zolidine-2-thione-4-carboxylic ethyl ester in the presence of N-methyl-2-chloropyridium salt.Products 1a,1b reacted with(R,S)-α-phenylethylamine in molar ratio 1:2 to produce the optically active N-(γ-methyl-δ-ketohexanoyl)-α-phenylethylamine,N-(γ-isopropyl-δ-ketohexanoyl)-α-phenylethylamine and op-tically active α-phenylethylamine.