艾司洛尔与地尔硫控制快速房性心律失常心室率即时疗效临床研究

Efficacy and safety of intravenous esmolol and diltiazem for controlling rapid atrial arrhythmias

目的观察并比较静脉注射艾司洛尔与地尔硫艹卓控制快速房性心律失常心室率的有效性。方法2001年3月～2004年9月65例快速房性心律失常(房颤、房扑、房速)患者随机分为2组,分别静脉注射艾司洛尔(30例)和地尔硫艹卓(35例)。结果艾司洛尔和地尔硫艹卓均能有效控制快速房性心律失常的心室率,心室率下降幅度分别为29.3%和27.6%,总有效率分别为83%和85%,平均用药有效时间分别为(10.0±3.9)分钟和(10.0±3.9)分钟。结论艾司洛尔及地尔硫艹卓均能有效、迅速、安全控制快速房性心律失常的心室率。

Objective To evaluate the efficacy of intravenous esmolol and dihiazem for controlling rapid atrial arrhythmias. Methods A total of 65 patients with rapid atrial arrhythmias were randomized to receive, intravenous esmolol（ n = 30） and diltiazem（ n =35 ）, respectively. Result The total efficacy rate were 83% and 85%, with a mean decrease in heart rate by 29.3% and 27.6% compared to baseline and mean response times were （ 10.0 ± 3.9 ） min and （ 10.0 ± 3.9 ） min, respectively. Conclusion Two drugs are all effective, rapidly and safe in acutely slowing of rapid ventricular rate in patients with rapid atrial arrhythmias.