摘要
在盐酸二甲双胍微丸外依次包滑石粉隔离层和Eudragit缓释层,并考察两者对体外释放度的影响。采用EudragitNE30D-L30D55(20∶1)包衣所得微丸表现出缓释特征,在体内与参比制剂生物等效。
The metformin hydrochloride pellets were coated in turn with talc powder and Eudragit as the isolating layer and Sustained-release layer. The effects of the two layers on the in vitro release of the pellets were investigated. The results showed that the pellets covered with Eudragit NE30D-L30D 55 （20 ： 1） had a sustained-release property and was bioequivalent to reference preparation.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2005年第9期541-544,共4页
Chinese Journal of Pharmaceuticals
关键词
盐酸二甲双胍
缓释
微丸
包衣
离心造粒
生物等效
metformin hydrochloride
sustained-release
pellets
coating
centrifugal granulation
bioequivalent
