纳米活性炭在小鼠体内的分布、存留及淋巴靶向性

Observation of the lymph tissue-targeting property, retention in the a bdomen and the distribution of the intraperitoneal activated carbon nano-partic les in mice

目的:观察纳米活性炭在腹腔及机体各脏器中的分布。方法:取昆明种小鼠经一次腹腔或尾静脉注射纳米活性炭,多次不同时间点解剖小鼠,观察纳米活性炭的去向及在腹腔的存留情况。结果:经腹腔注射的纳米活性炭在腹腔内有明显的淋巴趋向性,腹腔内纳米活性炭有随时间减少的倾向,经静脉注射的纳米活性炭随血液可以分布到全身各个脏器。结论:纳米活性炭在体内有明显的淋巴靶向性,肾脏及肠管可能对纳米活性炭有排泄作用,机体有能力排泄纳米活性炭。

Objective：To observe the distribution of the activated carbon nano-particles （ACN） in abdominal tissues and internal organs in mice. Methods： Mice were injected intravenously and intraperitoneally with the activated carbon nano-particles, and dissected at different time points after injection. Then the distribution and retention of black carbon particles were observed macroscopically and microscopically. Results： The intraperitoneal ACN had obvious lymph-tissue-targeting property. The retention in the abdominal tissues decreased as time went on after intraperitoneal injection. The intravenous ACN had wide distribution in the internal organs of the mice. Conclusion： Intraperitoneal ACN has lymph-tissue-targeting property and the intravenous ACN has wide distribution in internal organs of mice.