线粒体ATP敏感性钾通道:脑缺氧/缺血预适应保护的新焦点

Mitochondrial ATP sensitive potassium channel: a new target for brain protection in hypoxic/ischemic preconditioning

脑缺氧/缺血及药物等多种因素预适应对脑缺氧/缺血损伤有明显的保护作用。自Noma1983年发现心肌细胞膜上存在ATP敏感性钾通道(KATP)以来,KATP被认为是介导脑缺氧/缺血预适应重要的效应器。随着研究的深入,Inoue等于1991年在线粒体内膜发现了KATP,线粒体内膜ATP敏感性钾通道(mito-KATP)则成了人们新的关注焦点。虽然mito-KATP还没有被克隆出来,但现有相关领域的研究结果暗示mito-KATP将在脑缺血/缺氧预适应的脑保护中占有越来越重要的地位。

Preconditioning by hypoxia, ischemia, drug or other agents can protect brain against anoxic or ischemic injury. Since the discovery of ATP sensitive potassium channel（KATP） on cardiac myocyte in 1983 by Noma, it has been considered as a key effector mediating hypoxic or ischemic preconditioning. In 1991 Inoue discovered a special KATP on inner mitochondrial membrane of hepatocyte（mito-KATP） , which became a new focus attracting attention of many people for further investigation. Though mito-KATP has not been cloned up to now, the related research suggests that it may be a new target of hypoxic or ischemic preconditioning.