HERG编码的钾离子通道与新药评价

HERG potassium channel and drug evaluation

由人类ether--àgo-go相关基因(HERG)编码的钾离子通道在人类生理、病理过程中扮演着十分重要的角色。在心肌细胞中,HERG钾通道影响心脏动作电位的复极过程,是绝大多数能引起心肌细胞QT间期延长药物的作用靶标,它已成为新药研发早期,评价候选化合物心脏毒性的分子靶标。

The K^＋ channel encoded by the human ether-à-go-go related gene（HERG） plays a very important role in human physiological and pathological processes. HERG potassium channel determines the outward currents which facilitate the repolarization of the myocardial cells. Blockade of HERG channel usually results in a long QT interval and serious arrhythmia. Thus, HERG potassium channel has become a valuable target for screening leading compounds for QT interval prolongation in drug development program.