摘要
胎猪或新出生猪胸腺移植物可以在T细胞剔除的去胸腺小鼠中长期存活,并支持小鼠T细胞的正常发育分化,可使受者外周重新建立受者T细胞池。在异种猪胸腺成熟的小鼠T细胞具有正常的细胞免疫力,且受小鼠自身MHC的限制性。因此,异种胸腺移植可能为AIDS晚期患者或其他由于胸腺功能障碍引起的免疫缺陷性疾病等提供新的治疗手段或具有一定的辅助治疗作用。
出处
《国外医学(免疫学分册)》
2005年第5期257-259,共3页
Foreign Medical Sciences(Section of Immunology Foreign Medical Sciences)
参考文献12
-
1Markert ML, Sarzotti M, Ozaki DA, et al. Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients [J]. Blood,2003,102(3): 1121-1130.
-
2Markert ML, Alexieff M J, Li J, et al. Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome[ J]. Blood, 2004,104(8) :2574-2581.
-
3Vagefi PA, Ierino FL, Gianello PR, et al. Role of the thymus in transplantation tolerance in miniature Swine: Ⅳ. The thymus is required during the induction phase, but not the maintenance phase, of renal allograft tolerance [J]. Transplantation,2004,77(7) :979-985.
-
4Zhao Y, Swenson K, Sergio JJ, et al. Skin graft tolerance across a discordant xenogeneic barrier[J]. Nat Med, 1996,2(11): 1211-1216.
-
5Zhao Y, Rodriguez-Barbosa JI, Swenson K, et al. Highly disparate xenogeneic skin graft tolerance induction by fetal pig thymus in thymectomized mice: Conditioning requirements and the role of coimplantation of fetal pig liver[J]. Transplantation, 2001,72(10): 1608-1615.
-
6Zhao Y, Swenson K, Wekerle T, et al. Ther critical role of mouse CD4+cells in the rejection of highly disparate xenogeneic pig thymus grafts[J].Xenotransplantation,2000,7 (2): 129-137.
-
7Zhao Y, Rodriguez-Barbosa JI, Swenson K, et al. The induction of specific pig skin graft tolerance by grafting with neonatal pig thymus in thymectomized mice[J] .Transplantation,2000,69(7): 1447-1451.
-
8Rodriguez-Barbosa JI, Zhao Y, Barth R, et al. Enhanced CD4 reconstitution by grafting neonatal porcine tissue in altemative locations is associated with donor-specific tolerance and suppression of preexisting xenoreactive T cells[J]. Transplantation, 2001,72(7): 1223-1231.
-
9Zhao Y, Sergio JJ, Swenson K, et al. Positive and negative selection of functional mouse CD4 cells by porcine MHC in pig thymus grafts[J] .J Immunol, 1997,159(5) :2100-2107.
-
10Zhao Y,Fishman JA,Sergio JJ,et al. Immune restoration by fetal pig thymus grafts in T cell-dipleted, thymectomized mice[J] .J Immunol, 1997,58(4): 1641-1649.
同被引文献42
-
1徐剑,郑树森,梁廷波,谢海洋,沈克震,冯晓文,金雯佳.环孢素对大鼠同种胚胎后肾移植的影响[J].中华医学杂志,2005,85(18):1238-1242. 被引量:9
-
2张启旭,周刚,王春梅,吕福东,梁建萍,张子诚.非协调性异种气管移植的实验研究[J].中华整形外科杂志,2006,22(4):309-313. 被引量:2
-
3Griesemer AD, Sorenson EC, Hardy MA. The role of the thymus in tolerance. Transplantation, 2010, 90(5) : 465-474.
-
4Pujol-Borrell R, Herrero-Mata MJ, Palou E, et al. Immunological senescence and thymic function in transplantation. Transplanta- tion, 2009, 88(3 Suppl) : S8-13.
-
5Hammerman MR. Renal organogenesis from transplanted metane- phric primordia. J Am Soc Nephrol, 2004, 15(5) : 1126-1132.
-
6Bell EB, Sparshott SM, Dmyson MT, et al. The stable and per- manent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells. J Immunol, 1987, 139(5) : 1379-1384.
-
7Zarkhin V, Sarwal MM. Microarrays : monitoring for transplant tol- erance and mechanistic insights. Clin Lab Med, 2008, 28 (3) : 385-410.
-
8Starzl TE. The saga of liver replacement, with particular reference to the reciprocal influence of liver and kidney transplantation (1955-1967). J Am Coil Surg, 2002, 195(5) : 587-610.
-
9Zhao D, Qiu J, Wang C, et al. Vascularized whole thymus trans- plantation in Rowett nude rats: effect of thymus allograft volume on tolerance induction. Transpl Immunol, 2010, 23 (1-2) : 40-44.
-
10Yamada K, Shimizu A, Ierino FL, et al. Thymic transplantation in miniature swine. I. Development and function of the " thy- mokidney". Transplantation, 1999, 68( 11 ) : 1684-1692.
二级引证文献2
-
1徐太哲,李丽,王长山.小鼠胚胎胸腺移植方法和实验研究[J].黑龙江医药科学,2016,39(3):110-111.
-
2徐剑,孙亚辉,徐春岳,黄业宁,洪良杰,曾凡军.细胞排斥反应与不同胎龄大鼠后肾移植发育的关系研究[J].中华器官移植杂志,2019,40(6):369-373.
-
1姚根宏,商学军.17β-雌二醇抑制刀豆蛋白A诱导的胸腺细胞增殖能力[J].医学研究生学报,2005,18(7):588-590. 被引量:3
-
2梁学俭.复合蛋白锌与细胞免疫——增强细胞免疫有新法[J].科技信息,1998,0(11):46-46.
-
3梁学俭.复合蛋白锌与细胞免疫——增强细胞免疫有新法[J].科技信息,1998,0(9):47-47.
-
4张英博,刘国峰,李庆春,杨大平.胎猪脱细胞主动脉作为小口径组织工程血管替代物的体内试验研究[J].中国美容医学,2012,21(5):773-775. 被引量:2
-
5黄秀芬.图书的辅助治疗作用[J].内蒙古图书馆工作,2003(4):122-123. 被引量:3
-
6雷建平,彭燕,熊国亮,张玉珍,周军,刘翼军,邢娟娟,李光明,雷铭宙,袁小亮,涂荣耀,涂少华.卡介苗免疫大鼠的抗结核发病和CD4^+CD8^+双阳T细胞[J].实用临床医学(江西),2006,7(9):3-6. 被引量:1
-
7木子.我为什么感到孤独[J].心理月刊,2013(10):88-89.
-
8许冬梅,邸秀珍.胸腺肽α_1的作用机制及研究进展[J].中国民康医学,2014,26(2):79-82. 被引量:23
-
9李海涛.阿萨希毛孢子菌的全基因组测序[J].实用皮肤病学杂志,2013,6(2):126-126. 被引量:1
-
10吕佰瑞,刘朝奇.调节性T细胞与HIV感染相关性的研究进展[J].广东医学,2009,30(10):1565-1567. 被引量:2