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灰黄霉素及其在兔尿中代谢物的质谱研究 被引量:3

Study on Mass Spectrometry of Griseofulvin and Its Metabolit in Rabbit Urine
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摘要 本文报导了灰黄霉素及其在兔尿中代谢物(6-O-DMG)的EI质谱,并根据高分辨质谱(HRMS)数据讨论了它们的主要碎片裂解途径. The EI mass spectra of griseofulvin and its metabolit(6-O-dMG)in rabbit urine were reported.Their mass spectra fragmentations were decribed on the basis of high resolution mass spectrometry in the paper.
作者 余志立
机构地区 中国医学科学院
出处 《质谱学报》 EI CAS CSCD 1996年第1期72-75,共4页 Journal of Chinese Mass Spectrometry Society
关键词 灰黄霉素 代谢物 裂解途径 质谱 griseofulvin,metabolit,fragmentation
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参考文献2

  • 1丛浦珠,质谱学在天然有机化学中的应用,1987年
  • 2团体著者,抗菌素生物理化特性.1,1977年

同被引文献28

  • 1余志立.计算化合物分子式的3种方法[J].质谱学报,1996,17(4):68-72. 被引量:5
  • 2Bedford C, Child K J,Tomlch E G. Spectrophotofluorometric assay of griseofulvin[J]. Nature,1959,184:364 - 365.
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  • 6Schwarz H J, Waldman B A, Madrid V. GLC. determination of gris- eofulvln in human nlasma[J]. Pharm. Sci..1976.65 :370 - 372.
  • 7Kreuzig F. Determination of griseofulvin in rat plasma by high-per- formance liquid chromatography and high-performance thin-layer chromatography [ J ]. Chromatogrp, 1979,163:322 - 326.
  • 8Nation R L, Peng G W, Smith V,et al. Simple, rapid, and micro high-pressure liquid chromatographic determination of plasma griseo- fulvin levels[J]. Pharm. Sci., 67:805 - 808.
  • 9Meyer M C, Raghow G. High-pressure liquid chromatographic, assay for griseofulvin in plasma [ J ]. Pharm. Sei. , 1979,68 : 1127 - 1130.
  • 10Hackett L P, Dusci L J. Determination of griseofulvin in human ser- um using high-performance liquid chromatography [ J ]. Chromatogr,1978,155:206 - 208.

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