^(125)I密封籽源用于肿瘤治疗的动物实验初步研究

Primary study on animal test of ^(125)I sealed seed source for tumor therapy

目的:研究125I密封籽源对Hela细胞的杀伤作用以及对肿瘤的抑制作用。方法:通过内植入法将125I密封籽源植入荷瘤鼠的肿瘤内,观察其对肿瘤的抑制作用以及血液学毒性。结果:125I密封籽源对Hela细胞杀伤明显,照射48h的杀伤范围为1.6￣2.4mm,对肿瘤有明显的抑制作用,对血象和生化指标无明显影响。结论:125I密封籽源组织植入治疗法能有效抑制肿瘤的生长,并达到了治疗的效果。

Objective： To investigate antipersonnel effectiveness of Hela cell and therapeutic effectiveness of tumor of ^125I sealed seed source. Method： ^125I sealed seed source was implanted in tumor of bearingtumor mice, therapeutic effectiveness of tumor and toxicity of blood were observed. Result： ^125I sealed seed source had antipersonnel effectiveness for Hela cell, and the range of antipersonnel effectiveness was 1.6-2.4mm after 48h irradiation, and controlled patently the growth of tumor, toxicity of blood was not found . Conclusion： ^125I sealed seed source could control effectively the growth of tumor and obtain therapeutic purpose.