恶性骨肿瘤多药耐药的^(99)Tc^m-MIBI体层显像研究

Research of ^(99)Tc^m-MIBI SPECT imaging for assessment of multidrug resistance in Bone tumor

大多数肿瘤都有多药耐药-1(MDR-1)基因的过度表达,其表达产物P-糖蛋白(P-gp)在肿瘤的耐药机制中起着关键作用,对P-gp表达的预测在化疗中至关重要,99Tcm-甲氧基异丁基异腈(99Tcm-MIBI)转运分析可作为探测低水平的P-gp表达和定量评价调节转运的敏感指标,指导应用调节剂改善化疗效果。

There has a overexpression ofmultidrug resistance （MDR） gene in most tumor. It is very important that it＇s expression product P-glycoprotein（P-gp）in multidrug resistance machine of tumor. The anticipation for P-gp expression is significance for chemotherapy. The conveying analysis of ^99Tc^m-sestamibi （^99Tc^m-MIBI） is a sensitiveness index for low-level P-gp expression.