Survivin、PCNA在乳腺癌中的表达及其意义

EXPRESSIONS OF SURVIVIN AND PCNA IN BREAST CARCINOMA AND THEIR CLINICAL SIGNIFICANCE

目的:探讨凋亡抑制蛋白(Survivin)、增殖细胞核抗原(Proliferatingcellnuclearantigen,PCNA)在乳腺癌中的表达及其临床意义。方法:用免疫组化染色检测74例乳腺癌组织中Survivin和PCNA蛋白的表达情况。结果:在乳腺癌组织中,Survivin蛋白的阳性表达率为64.86%;Survivin蛋白表达阳性的乳腺癌细胞PCNA的标记指数达61.17%,明显高于Survivin蛋白表达阴性者的51.26%(P<0.05);乳腺癌中Survivin、PCNA阳性高表达者腋窝淋巴结转移率明显高于低表达者(P<0.05),5年生存率明显低于低表达及阴性者(P<0.05)。乳腺癌中Survivin、PCNA阳性表达与临床分期密切相关(P<0.05),与组织学分期无明显相关(P>0.05)。结论:检测Survivin及PCNA蛋白在乳腺癌组织中的表达,有助于乳腺癌进展和预后的判断。

Objective： To investigate the expressions of Survivin and proliferating cell nuclear antigen （PCNA） in breast carcinoma and their clinical significance. Methods： The expressions of Survivin and PCNA were tested by immunohistochemical method in 74 cases of breast carcinoma. Result： In the breast carcinoma, the positive expression rate of Survivin was 64.86 %. Labeling indexes of PCNA in breast carcinoma tissues with positive expression of Survivin reached 61.17 % and was significantly higher than that with negative expression of Survivin （51.26 % ） （P〈0.05）. The rate of lymph node metastasis in the group of strong positive co-expression of the two genes was much higher than that in low positive or negative expressions of survivin and PCNA （P〈0.05）, but the 5 year survival rate was much lower than that in low positive or negative expression of Survivin and PCNA （P〈0.05）. The expressions of Survivin and PCNA were closely correlated with clinical staging（P〈0.05）, but was no significant correlation with histological types（P〉 0.05）. Conclusion： Testing expressions of Survivin and PCNA could be served as indictors for evaluating the metastasis and prognosis in breast cancer.