甘草酸二胺注射液治疗化疗所致药物性肝损害临床疗效观察

Ganlixin injection solution in treatment of hepatic-lesion caus ed by chemotheraphy

目的:观察甘草酸二胺注射液治疗化疗所致药物性肝损害的效果。方法:化疗后出现药物性肝损害的患者88例随机分为两组,甘草酸二胺组45例,给予甘草酸二胺30 ml加入10%葡萄糖注射液250 ml中静脉滴注,每天1次;甘草酸单胺组43例给予甘草酸单胺60 ml加入10%葡萄糖注射液250 ml中静脉滴注,每天1次;分别在治疗5天和10天后进行疗效评定,对治疗前后肝功能指标丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、γ-谷氨酰转移酶(-γGT)进行对比分析。结果:治疗后5天甘草酸二胺组有效率55.56%,甘草酸单胺组30.23%(P<0.05),治疗后10天甘草酸二胺组有效率88.89%,甘草酸单胺组55.81%(P<0.01),各项肝功指标对比提示甘草酸二胺的降酶作用显著。结论:甘草酸二胺注射液治疗化疗后所致药物性肝损害经济安全有效。

Objective： To observe the effect of ganlixin in treating hepatic-lesion caused by chemotheraphy. Methods： Eighty-eight patients with hepatic-lesion related to chemotherathy were randomly divided into two groups. Forty-five cases were administrated ganlixin at a dose of 30 ml/d with 10 percent of 250 ml glucose solution by injection,and 43 cases received qianglilin at a dose of 60mg/d with 10 percent of 250 ml glucose solution by injection. The effect was evaluated with hepatic function marker, such as AST, ALT and r-GT 10 days after treatment. Results：The recovery rate of ganlixin group was 88.89% ,while the recovery rate of qianglilin group was 55,81% （P 〈 0.01 ）. Conclusions： The result indicates that ganlixin is more effective than qianglilin in treatment of hepatic-lesion.