摘要
衰老是一种多因素的复合调控过程,表现为染色体端粒长度的改变、DNA损伤、DNA的甲基化和细胞的氧化损害等,并已形成了许多学说,而端粒学说成为衰老研究的热点。本文综述了与衰老紧密相关的因素———端粒、端粒酶的结构及其与衰老和年龄关系的研究进展,阐明对端粒—端粒酶的作用将会在抗衰老方面有着十分重要的理论价值及实际意义。此外,利用端粒长度变化与年龄的相关性评估人的年龄将在法医学界显示其巨大的应用前景。
Aging is a complex regulatory process, involving telomere alterations, DNA damage, DNA methylation and cellular oxidation. Many theories have been proposed to explain the aging process. However, telomeres are supposed to play a important role in cellular aging, and the telomere hypothesis of cell aging is becoming hot spot. Here we have reviewed the structures and functions of telomere-telomerase and the association between telomere-telomerase and aging/age, which will manifest impotant theorical and practical significance in antiaging. In addition, estimating age of humans based on telomere shortening will display enormous applicational prospect in forensic medicine.
出处
《解剖科学进展》
CAS
2005年第3期261-264,共4页
Progress of Anatomical Sciences
基金
国家自然科学基金资助项目(30270696)
