摘要
目的探讨超声引导下经皮集束电极射频消融治疗肾肿瘤的可行性和有效性.方法将42只已建立肾VX2肿瘤模型的大白兔随机分为对照组15只和治疗组27只,对治疗组行超声引导下射频经皮消融肿瘤结节,对照组未行处理,应用超声显像技术分别于治疗前、治疗中和治疗后按不同时间点观察两组肿瘤大小、回声及形态,至兔自然死亡时比较肿瘤生长和肺转移情况,计算生存率.结果①27只兔均经超声引导穿刺成功,射频治疗时间27～220 s;②射频治疗后3 d、7 d、14 d、21 d肿瘤平均直径均小于对照组(P<0.05),治疗组肿瘤生长较对照组明显缓慢;③治疗组与对照组荷瘤生存时间差异有显著性意义[(45.1±9.5)d 对 (33.7±6.9)d, P<0.05];④同一时间点治疗组荷瘤肾明显小于对照组,肺转移结节数治疗组少于对照组.结论超声引导下集束电极射频消融肾肿瘤可延长生存期,操作简便,安全、有效.
Objective To study the feasibility and effectiveness of cluster electrode percutaneous radiofrequency ablation guided by ultrasonography in renal tumor. Methods Forty-two rabbits carrying renal VX2 tumor were divided into treated group and control group randomly （27 and 15 rabbits, respectively）. Radiofrequency ablation under the guidance of ultrasonography was performed in the treated group. The tumors were evaluated by two-dimensional ultrasonography for the changes of the shape and the echo pre- and post-treatment, during the course of treatment and post operation. Necropsy was performed on all the animals after they died naturally. Tumor state metastasis rate and survival rate were compared. Results ① Paracentesis was performed successfully on all the animals and the treating time was 27-220 seconds.② Tumor size in the treated group was smaller than that in control group from 3 d,7 d, 14 d and 21 d operation（ P〈0.05）. Growth velocity of the tumor in the treated group was slower than that of control group. ③The difference of survival rate between the treated group and control was significant[（45.1±9.5） d vs （33.7±6.9）d, P 〈0.05]. ④Tumor size in renal tissue in the treated group was smaller than that of control group. Metastasis node number in lung tissue in the treated group was fewer than that of control group. Conclusions The treatment of cluster electrode radiofrequency ablation guided by ultrasonography in renal tumor can lengthen the survival time. The management is safe and effective.
出处
《中华超声影像学杂志》
CSCD
2005年第9期698-701,共4页
Chinese Journal of Ultrasonography
基金
陕西省科学基金(2001SM47)
