摘要
尽管诊断技术进步，不明原因发热（PUO）仍然是严重的挑战。1961年PUO的定义是病程超过3周，多次体温超过38．3℃，经住院检查1周后仍然诊断不明者。该定义已做修改，不再要求住院检查，并除外免疫抑制患者，但免疫抑制患者需作鉴别诊断，并需不同的治疗。
Despite recent advances in diagnostic techniques, pyrexia of unknown origin（PUO） remains a formidable diagnostic challenge. In 1961, PUO was defined as an illness of more than 3 weeks＇ duration, fever of more than 38.3℃ on several occasions, and diagnosis uncertain after 1 week of study in the hospital. This definition has been modified by removing the requirement that the evaluation must be in hospital and by excluding immunocompromised patients, in whom a different diagnostic and theraoeutic approach is reauired.
