生长抑素联合氧化苦参碱治疗重症急性胰腺炎

Combined use of Sandostatin and Oxymatrine in the treatment of severe acute pancreatitis.

目的观察善得定和氧化苦参碱联合应用治疗重症急性胰腺炎的疗效。方法32例重症急性胰腺炎患者随机分为两组,A组15例,为生长抑素治疗组,B组17例,为生长抑素联合氧化苦参碱治疗组,观察患者治疗后临床症状缓解时间、并发症发生率、平均住院时间,以及治疗前和治疗后1周APACHE Ⅱ评分。结果两组治疗无效率无显著差异(P>0.05),但B组症状缓解时间、并发症发生率、平均住院时间及治疗1周后APACHEⅡ评分均显著小于A组(P<0.05或P<0.01)。结论联合应用善得定和氧化苦参碱治疗重症急性胰腺炎有协同作用,疗效优于单一的西药治疗。

Objective To investigate therapeutic effects of combined use of Sandostatin and Oxymatrine in the treatment of severe acute panereatitis （SAP）. Methods Thirty-two SAP patients were randomly divided into two groups： Group A （n - 15, treated with Sandostatin, and Group B （n - 17）, treated with both Sandostatin and Oxymatrine. Relief of the clinical symptoms, the incidence of complication and average hospital stay were observed. APACHE Ⅱ scores of a week after treatment were tested. Results There was no significant difference in the rate of therapeutic failure between the two groups （P 〉0.05）. The clinical symptoms, the incidence of complication and average hospital stay were all reduced significantly in Group B than in Group A （P〈 0.05 or P〈 0.01）. APACHE Ⅱ scores of a week after treatment were lower greatly in Group B than in Group A （P〈 0.05）. Conclusions Combined use of Sandostation and Oxymatrine is superior to a single western medicine in the treatment of severe acute pancreatitis.