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加贝酯防治急性胰腺炎应用现状 被引量：15

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摘要 甲磺酸加贝酯(gabexate mesilate, GM)是20世纪70年代日本研制的一种新的非肽类蛋白水解酶抑制剂,是第一个用于治疗胰腺炎的化学合成药物,分子质量为417,无免疫原性,副作用小.GM在人血中半衰期为55 s,由肝脏代谢,肾脏排泄,易于渗入胰腺组织.临床上常用于治疗急性胰腺炎(acute pancreatitis, AP)、慢性胰腺炎急性发作,还可用于治疗弥散性血管内凝血(DIC).本文就其防治AP作用机制、疗效评价、剂量及用法作一综述.
作者 彭国林 李兆申
机构地区 第二军医大学长海医院消化内科
出处 《胰腺病学》 2005年第3期177-179,共3页 Chinese JOurnal of Pancreatology
关键词 甲磺酸加贝酯 急性胰腺炎 非肽类蛋白水解酶抑制剂 防治 mesilate 弥散性血管内凝血 化学合成药物 慢性胰腺炎 20世纪
分类号 R576 [医药卫生—消化系统]
  • 相关文献

参考文献20

  • 1Di Francesco V, Mariani A, Angelini G, et al. Effects of gabexate mesilate, a protease inhibitor, on human sphincter of Oddi motility. Dig Dis Sci, 2002, 47:741-745.
  • 2吴叔明,徐华,戈之铮,莫剑忠,陈胜良,杨川华.加贝酯对Oddi括约肌运动的影响[J].中华消化杂志,2004,24(8):464-467. 被引量：26
  • 3Messori A, Rampazzo R, Scroccaro G, et al. Effectiveness of gabexate mesilate in acute pancreatitis. A meta-analysis. Dig Dis Sci, 1995, 40:734-738.
  • 4Mayumi T, Ura H, Arata S, et al. Evidence-based clinical practice guidelines for acute pancreatitis: proposals. J Hepatobiliary Pancreat Surg, 2002, 9:413-422.
  • 5Buchler M, Malfertheiner P, Uhl W, et al. Gabexate mesilate in human acute pancreatitis. German pancreatitis study group. Gastroenterology, 1993, 104:1165-1170.
  • 6Andriulli A, Leandro G, Clemente R, et al. Meta-analysis of somatostatin, octreotide and gabexate mesilate in the therapy of acute pancreatitis. Aliment Pharmacol Ther, 1998, 12:237-245.
  • 7Seta T, Noguchi Y, Shimada T, et al. Treatment of acute pancreatitis with protease inhibitors: a meta-analysis. Eur J Gastroenterol Hepatol, 2004, 16:1287-1293.
  • 8Pelagotti F, Cecchi M, Messori A, et al. Use of gabexate mesylate in Italian hospitals: a multicentre observational study. J Clin Pharm Ther, 2003, 28:191-196.
  • 9Chen HM, Chen JC, Hwang TL, et al. Prospective and randomized study of gabexate mesilate for the treatment of severe acute pancreatitis with organ dysfunction. Hepatogastroenterology, 2000, 47:1147-1150.
  • 10Yang CY, Chang-Chien CS, Liaw YF. Controlled trial of protease inhibitor gabexelate mesilate (FOY) in the treatment of acute pancreatitis. Pancreas, 1987, 2:698-700.

二级参考文献5

  • 1Aliperti G. Complications related to diagnostic and therapeutic endoscopic retrograde cholangiopancreatography. Gastrointest Endosc Clin North Am, 1996,6: 379-407.
  • 2Chen YK, Foliente RL, Santoro MJ, et al. Endoscopic sphincterotomy-induced pancreatitis: Increased risk associated with nondilated bile ducts and sphincter of Oddi dysfunction. Am J Gastroenterol ,1994,89: 327-333.
  • 3Cavallini G, Tittobello A, Frulloni L, et al. Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. N Engl J Med, 1996, 335:919-923.
  • 4Matsumura T, Yada S, Miyoshi Y, et al. Effect of synthetic protease inhibitor on the sphincter of Oddi function in dogs. Nippon Shokakibyo Gakkai Zasshi, 1991, 88:2663-2670.
  • 5Di Francesco V, Marriani A, Angelini G , et al. Effects of gabexate mesilate,a protease inhibitor, on human sphincter of Oddi motility.Dig Dis Sci, 2002, 47:741-745.

共引文献25

同被引文献123

引证文献15

二级引证文献69

胰腺病学
2005年 第3期

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