CYP2C9基因多态性与肺癌的危险度关系初探

Genetic polymorphism of CYP2C9 and the risk of lung cancer

目的探讨细胞色素P450 2C9(CYP2C9)基因多态性与肺癌易感性的关系.方法用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)法分析56例肺癌(肺癌组)和42例健康人群(对照组)AvaⅡ、Nsi Ⅰ识别的CYP2C9基因型.结果突变型CYP2C9*3基因发生频率在肺癌组中为8.93%,高于对照组的4.76%,差异未达显著性(P＞0.05),肺癌组与对照组比OR值为1.96(95%的可信区间为0.63～10.33);肺癌组、对照组均未检测出突变型CYP2C9*2基因型.结论本研究未发现突变型CYP2C9*3基因型与肺癌的显著性联系.

Objective To evaluate the relationship between the polymorphism of genes CYP2C9 and the susceptibility to lung cancer. Methods The patients with lung cancer （LC group, n = 56） diagnosed clinically or/and cytologically were selected. And the control group（n =42） were also selected from the same areas. The genotype frequencies of Ava Ⅰ and Nsi Ⅱ were analysed with Polymerase Chain Reaction-Restriction Fragment length Polymorphlism （PCR-RFLP） in the LC group and the control group. Results The mutation genotype of CYP2C9^＊3 was found in LC group （8.93%） , which was not significantly higher than that in the control group （4. 76 % ）, and the OR = 1.96 （ 95 % CI = 0. 63 - 10.33 ）. The mutation genotype of CYP2C9^＊ 2 was not found in both the LC group and the control group. Conclusion There was no association between the mutation genotype of CYP2C9^＊ 3 and the susceptibility of lung cancer in this study.