COX模型对肝癌预后因素的分析

Analysis of Prognostic Factors Using Cox's Model in Patients of Liver Cancer Treated by Interventional Therapy.

用 COX 模型,回顾性计量分析621例用导管灌注栓塞治疗的不能切除的晚期肝癌患者的预后因素。结果显示最有意义的预后因素是肿瘤大小和门静脉癌栓。1,3,5年总生存率为62.23%,12.85%和7.45%。中位存活时间为16.23月。论文结果提示对晚期肝癌最有效的治疗是栓塞治疗。有关预后因素的知识有益于患者选择治疗。

Using the Cox's proportional hazard model,we retrospectively and sta- tistically analysed 621 cases of unresectable late hepatic carcinoma treated with transcatheter arterial embolization of infusion during the period from 1986 to 1992.The results were as follows:the most significant prognostic factors were tumor size;tumor embolus in the portal vein and modality of treatment,the overall commulative survival rates for 1—,3—,and 5— year were 62.23%,12.85% and 7.45% respectively,and the median duration of survival was 16.23 months.Our findings suggested that combination therapy (LpGsTACE) is the best modality for treatment of hepatocellular carcinoma.Furthermore,knowledge of the prognostic factors is useful for the selection and management of patients.