肝动脉化疗、栓塞与肝静脉暂时闭塞治疗肝癌

Treatment of Hepatocellular Carcinoma by Transcatheter Hepatic Arterial Infusion Chemotherapy,Embolization,and Transient Occlusion of Hepatic Vein

本文报道在10例肝癌患者中运用肝静脉暂时闭塞和肝动脉内灌注化疗、栓塞的方法治疗取得较好疗效。7例甲胎蛋白阳性患者5例下降大于50%,2例转阴。4例肿瘤缩小>50%。2例合并肝动-静脉瘘者成功实行碘油栓塞,1例经治疗后肝动-静脉瘘消失。对肝功能的影响与普通介入治疗相同。消化道反应相对较轻。并可提高肿瘤局部药物浓度,延长药物作用时间。配合肝段动脉或靶血管的插管可进一步提高疗效,减少并发症。

This paper reported that in 10 patients with hepatocellular carcinoma, good therapeutic effects were obtained by using transient occulsion of hepatic vein and hepat- ic arterial infusion chemotherapy and embolization.In 7 patients with abnormal AFP,its value decreased >50% in 5 cases,and turned normal in 2 cases.Tumor diminished >50% in size in 4 cases.Lipiodal embolization was successfully performed in 2 patients with hepatic A-V fistula.In one case,it disappeared after treatment.The effect of the above method on liver functions was the same as that in traditional interventional therapy.The reactions of al- imentary tract were relatively reduced.Durg concentration in the tumor was also increased and the time of drug effect lengthened.Therapeutic effects may be further increased and complications reduced by the above method combined with hepatic segmental arterial or tar- get blood vessel catheterization.