摘要
目的探讨脂联素在2型糖尿病发生发展中的作用。方法选择140例2型糖尿病患者,将体质指数(BMI)<25者定为非肥胖糖尿病组,BMI≥25者定为肥胖糖尿病组。选择80例健康者作为正常对照组。用ELISA方法检测空腹血清脂联素浓度,同时测定各组的血糖、血脂、血压、胰岛素等,分析各指标与血清脂联素的相关性。结果①糖尿病组血清脂联素水平为(5.64±3.29)μg/ml,明显低于正常对照组的(13.47±6.94)μg/ml(P<0.001),肥胖糖尿病组血清脂联素水平为(4.77±3.29)μg/ml,低于非肥胖糖尿病组(P<0.001),有显著性差异。②血清脂联素与性别因素有关,单因素相关分析显示血清脂联素与BMI、腰臀比呈负相关,与高密度脂蛋白$胆固醇HDL$C呈正相关。③多因素回归分析显示,腰臀比、HDL$C为影响脂联素水平的最为显著的因素。结论血清脂联素与肥胖及血脂异常相关,脂联素的增高可能是有益的。
Objective To explore the role of adiponectin in type 2 diabetes. Methods Serum adiponectin level was measured by ELISA. Plasma glucose, lipid profiles and insulin were also measured on fasting samples.The correlation of serum adiponectin and other facts were analysised. Results ① The level of serum adiponectin was significantly decreased in diabetic group compared with that of the control group.The adiponectin concentration of DM2 group was significantly decreased compared to DM1 group. ② Serum adiponectin was correlated with gender. It was correlated negatively with BMI and that WHR, positively with HDL-C. ③ Multiple regression analysis showed that WHR and HDL-C were significantly independent determinants for serum adiponectin concentration. Conclusions Serum adiponectin is correlated with obesity and abnormal lipid profiles. Therefore, any treatment which increase adiponectin seems to be beneficial.
出处
《北京医学》
CAS
2005年第9期513-515,共3页
Beijing Medical Journal
基金
国家科技部基金资助项目(编号2001BA702B01)