2型糖尿病患者血清脂联素水平及影响因素的研究

The study of serum adiponectin and related factors in newly diagnosed type 2 diabetic patients

目的探讨脂联素在2型糖尿病发生发展中的作用。方法选择140例2型糖尿病患者,将体质指数(BMI)<25者定为非肥胖糖尿病组,BMI≥25者定为肥胖糖尿病组。选择80例健康者作为正常对照组。用ELISA方法检测空腹血清脂联素浓度,同时测定各组的血糖、血脂、血压、胰岛素等,分析各指标与血清脂联素的相关性。结果①糖尿病组血清脂联素水平为(5.64±3.29)μg/ml,明显低于正常对照组的(13.47±6.94)μg/ml(P<0.001),肥胖糖尿病组血清脂联素水平为(4.77±3.29)μg/ml,低于非肥胖糖尿病组(P<0.001),有显著性差异。②血清脂联素与性别因素有关,单因素相关分析显示血清脂联素与BMI、腰臀比呈负相关,与高密度脂蛋白$胆固醇HDL$C呈正相关。③多因素回归分析显示,腰臀比、HDL$C为影响脂联素水平的最为显著的因素。结论血清脂联素与肥胖及血脂异常相关,脂联素的增高可能是有益的。

Objective To explore the role of adiponectin in type 2 diabetes. Methods Serum adiponectin level was measured by ELISA. Plasma glucose, lipid profiles and insulin were also measured on fasting samples.The correlation of serum adiponectin and other facts were analysised. Results ① The level of serum adiponectin was significantly decreased in diabetic group compared with that of the control group.The adiponectin concentration of DM2 group was significantly decreased compared to DM1 group. ② Serum adiponectin was correlated with gender. It was correlated negatively with BMI and that WHR, positively with HDL-C. ③ Multiple regression analysis showed that WHR and HDL-C were significantly independent determinants for serum adiponectin concentration. Conclusions Serum adiponectin is correlated with obesity and abnormal lipid profiles. Therefore, any treatment which increase adiponectin seems to be beneficial.