他汀类非调脂作用在稳定急性冠脉综合征病变斑块的机制

Mechanism of Statins’ Noncholesterol-lowering Effects on Stabilizing Atherosclerotic Plaques of Acute Coronary Syndrome

急性冠脉综合征主要由斑块破裂、血栓形成所致。他汀类属羟甲基戊二酸辅酶A还原酶抑制剂,除调脂作用之外尚有非调脂作用,即多向性效应。它包括抗炎作用,逆转内皮功能失调,降低动脉粥样硬化斑块的脆性,抗血小板凝聚和减少血栓形成等效应,在稳定急性冠脉综合征病变斑块方面发挥着重要作用。

Acute coronary syndrome is mainly cattsed by rupttlre of atherosclerotic plaques which causing thrombotic formation. Hydroxymethylglutaryl coenzyme A reductase inhibitors, statins,are not only lowered serum hypercholesterolemia,but also have noncholesterol-lowering effects or pleiotropic actions. It involves in anti-inflammatory effects, reversion of endothelial dysfunction, reducing brittleness of atherosclerotic plaques, antl-thrombotic effects and redtlce thrombotic formation. They exert an importance of stabilizing atherosclerotic plaque of acute coronary syndrome.