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Toll样受体4与动脉粥样硬化 被引量：1

Toll-like Receptor 4 and Atherosclerosis
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摘要 动脉粥样硬化是一种慢性炎症疾病。Toll样受体家族(TLRs)识别抗原相关的分子模式(PAMPs)后激发先天性免疫反应。TLR4不仅识别外源性配体脂多糖(LPS),也识别动脉损伤过程中表达的内源性配体。越来越多的研究表明TLR4可能在动脉粥样硬化病变的发生和发展过程中发挥主要作用。现对近年有关TLR4在动脉粥样硬化中的作用的研究进展作一综述。此外,还将讨论对TLR4信号的可能干预措施。 Atherosclerosis is a chronic inflammatory disease, The family of Toll-like receptors （ TLRs） initiates an innate immune response after recognition of pathogen-associated molecular patterns （ PAMPs ）, TLR4 recognizes not only exogenous ligands but also endogenous ligands that are expressed during arterial injury. Evidence is accumulating that TLR4 might play an important role in the initiation and progression of atherosclerotic disease. This review will summarize the latest progression in research on the role of TLR4 in atherosclerotic disease, In addition,the potential of intervention in TLR4 signalling to influence progression of atherosclerotic disease is discussed.
作者 王虹艳 曲鹏
机构地区 大连医科大学附属第二医院心血管内科
出处 《心血管病学进展》 CAS 2005年第B08期17-20,共4页 Advances in Cardiovascular Diseases
关键词 动脉粥样硬化 炎症 先天免疫 TOLL样受体4 Atherosclerosis Inflammation Innate immunity Toll-like receptor 4
分类号 R543 [医药卫生—心血管疾病]
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参考文献26

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同被引文献22

  • 1丁涵露,张建国,朱妙珍,罗向东,梁光萍.高浓度的糖刺激人肾小球内皮细胞表达单核细胞趋化蛋白-1的影响[J].细胞与分子免疫学杂志,2004,20(4):450-453. 被引量：6
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  • 7Park C W,Kim J H,Lee J H,et al.High glucose-induced intercellular adhesion molecule-1 (ICAM-1) expression through an osmotic effect in rat mesangial cells is PKC-NF-kappa B-dependent[J].Diabetologia,2000,43 (12):1544-1553.
  • 8FY Chow,DJ Nikolic-Paterson,E Ozols,et al.Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice[J].Kidney International,2006,69(1):73-80.
  • 9Mohammad MK,Michael Morran,Brandon Slotterbeck,et al.Dysregulated toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse[J].International immunology,2006,18(7):1101-1113.
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心血管病学进展
2005年 第B08期

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