摘要
血管紧张素Ⅱ(AngⅡ)可刺激多种细胞分泌多种炎症因子,炎症与动脉粥样硬化存在高度相关性。多种细胞因子可诱导产生炎症标志物,炎症因子与炎症标志物直接参与动脉粥样硬化的形成,同时也介导甚至加强AngⅡ的致动脉粥样硬化作用。在AngⅡ、炎症因子、炎症标志物之间可能存在着一种复杂的网状联系,AngⅡ是这个网状联系的结点之一,具有关键作用;尚不能确定一种炎症因子或炎症标志物可作为这个网状联系的结点。在动脉粥样硬化性疾病的预防和治疗中对AngⅡ和炎症的抑制可获得良好的效果。
Angiotensin Ⅱ （ Ang Ⅱ ） is able to stimulate multiple cells in atherosclerotic tissues to express a number of inflammatory factors. Inflammation correlates with atherosclerosis. The markers of inflammation can be induced by multiple cytokines. Inflammatory factors and the markers of inflammation directly participate in the formation of atherosclerosis, and simultaneously mediate or even enhance the proatherogenic effect of Ang Ⅱ . There is a netlike linkage among Ang Ⅱ , inflammatory factors, and the markers of inflammation. Ang Ⅱ is a node of netlike linkage and is on pivotal location and any one of factors and markers of inflammation has not yet been affirmed as a node ofnetlike linkage. The prevention and therapy of atherosclerotic diseases will benefit from the inhibition of Ang Ⅱ and inflammation.
出处
《心血管病学进展》
CAS
2005年第B08期105-108,共4页
Advances in Cardiovascular Diseases
