血清锌与T细胞亚群在RAU患者中的检测及分析

Detection and analysis of zinc and T lymphocyte subsets in patients with RAU

目的通过对复发性口疮(recurrent aphthors ulcer,RAU)患者锌及T细胞亚群的测定,探讨锌与T细胞亚群在RAN患者中的变化及相互关系。方法选择RAU患者50例,健康成人(正常对照组)40例作对照研究,分别取静脉血光谱分析仪测定锌含量和用间接免疫荧光法检测T细胞亚群并加以比较。结果RAU患者的锌含量明显低于正常对照组,差异有统计学意义(P<0.05);T淋巴细胞亚群中CD3、CD4、CD4/CD8明显降低,CD8则升高,与正常对照组均有统计学意义(P<0.05)。RAU患者血清锌与CD3(rs=0.195,P>0.05)、CD4(rs=0.212,P>0.05)、CD8(rs=-0.253,P>0.05)、CD4/CD8(rs=-0.168,P>0.05)的相关性均无统计学意义。结论RAU患者血清锌和T细胞亚群功能低下,但二者的相关性无统计学意义。

Objective： To detect the changes and relationship of zinc and T lymphocyte subsets in patients with recurrent aphthous ulcer （RAU） .Methods： The venous bloods were collected from 50 patients with RAU and 40 adult healthy persons, the zinc was detected by spectrometry and T lymphocyte subsets by indirect immunofluorescence. Results： The serum zinc in RAU was lower than that in normal subjects [ （0.7125 ± 0. 0695）mg/L vs （0. 9639 ± 0. 1293） mg/L, （P 〈 0.05） ] ;T lymphocyte subsets also changed, CD3, CD4 and CD4/CD8 decreased （P 〈 0.05） and CD8 increased significantly（ P 〈 0.05）. There were no statistical differences between Zn and CD3, CD4, CD8, CD4/CD8（rs = 0. 195, P 〉 0.05, rs = 0.212, P 〉 0.05, rs = - 0. 253, P 〉 0.05, rs = - 0. 168, P 〉 0.05 ） . Conclusion： The function of zinc and cellular immunity in RAU is low,but there is little relationship between zinc and T lymphocyte subsets in RAU.