血清血管紧张素转换酶的测定与临床应用

Determination and clinical significance of the serum angiotension-converting enzyme

目的测定肺癌与慢性阻塞性肺部疾病(COPD)患者血清血管紧张素转换酶(SACE)的活性,评价其临床意义。方法选择100例正常人、38例肺癌、64例COPD患者,运用7170全自动生化分析仪,采用速率法测定SACE的活性。结果肺癌患者的SACE活性明显低于正常对照组(P<0.05),COPD组的SACE活性降低,但与正常对照组差异无显著性(P>0.05)。结论ACE的改变与肺癌有密切关系,可能成为临床诊断的途径。

Objective： To study the clinical significance of the activity of the serum angiotension- converting enzyme（SACE） in patients with cancer and chronic obstructive pulmonary disease （COPD）. Methods： 100 normal subjects, 38 patients with lung cancer and 64 patients with COPD were chosen. The activity of SACE was detect with FAP by 7170 antomatie analysizer. Results：The level of the activity of SACE in patients with lung cancer was significantly lower than that of healthy control group（P 〈 0.05） ,but the level of the activity of SACE in COPD group was slighdy lower than that of the normal（P 〉 0.05）. Conclusion： The determination of the activity of SAGE may be helpful in the clinical diagnosis Of lung cancer.