去白细胞单采血小板的临床应用

Clinical Application of Apheresis Platelets with Leukocyte Filtration

【目的】研究保存前白细胞过滤与保存后白细胞过滤对单采血小板临床输注效果及非溶血性发热输血反应(FNHTR)发生率的影响。【方法】46例肿瘤化疗后血小板减少患者,分别输注保存前过滤单采血小板(保存前组)与保存后过滤单采血小板(保存后组),输注后1 h及24 h后检测外周血小板计数,以校正血小板计数增殖(CCI)判定输注效果,并考查FNHTR发生率。【结果】保存前组与保存后组其1 h及24 h CCI值无明显差异(P>0.05),但保存前组FNHTR发生率要明显低于保存后组(P<0.05)。【结论】两种方法制备的单采血小板均能有效地治疗血小板减少,但保存前过滤能更有效地减少FNHTR的发生率。

[Objeetive]To study the effect of prestorage and poststorage leukocyte filtration on apheresis platelets transfusion and the incidence rate of febrile nonhemolytic transfusion reactions（FNHTR）. [Methods] Prestorage （Prestorage group） and poststorage （Poststorage group） leukocyte filtration apheresis platelets were transfused respectively to patients with malignancy accompanied by serious thrombocytopenia after chemotherapy. Peripheral blood platelet counts were made at lh, 24h after platelet transfusion. The effectiveness was assayed by correct count increment （CCI）. The incidence rates of FNHTR were explored. [Results]The lh and 24h CCI between prestorage and poststorage groups were of no difference（ P〉0. 05）, but the incidence rate of FNGTR of poststorage group was much higher than that of prestorage group（ P〈0.05）. [Conclusion] Apheresis platelets by both preparations show excellent transfusion results in curing thrombocytopenia, but prestorage leukocyte filtration can effectively reduce the incidence rate of FNHTR.