丹参注射液治疗慢乙肝肝硬化血栓前状态的研究

Study on Prethrombotic State in Patients with Chronic Hepatitis B or Liver Cirrhosis Treated with Salvia Injection

目的:研究丹参注射液对慢乙肝肝硬化血栓前状态的治疗作用。方法:测定慢乙肝肝硬化患者血栓学指标:血管假性血友病因子(vWF)、D-二聚体(D-D)和血清纤维蛋白降解产物(FDP),根据血栓前状态的纳入标准明确慢乙肝肝硬化患者是否存在血栓前状态,将存在血栓前状态的患者随机分成两组:治疗组和对照组,两组间无统计学差异,具有可比性。治疗组在对照组的基础上加用丹参注射液治疗,疗程为4周。治疗结束后再次测定上述指标并进行两组间比较。结果:治疗前治疗组和对照组vWF、FDP和D-D测定值分别为:(230·81±78·39)%、(8·20±3·15)mg/L、(0·73±0·14)μg/ml和(243·37±79·85)%、(8·29±2·89)mg/L、(0·80±0·17)μg/ml;治疗后治疗组和对照组vWF、FDP和D-D测定值分别为:(104·41±50·89)%、(3·89±1·37)mg/L、(0·41±0·15)μg/ml和(241·96±80·86)%、(8·26±2·83)mg/L、(0·79±0·17)μg/ml。治疗前后比较治疗组vWF、FDP和D-D测定值有非常显著性差异(P<0·001);两组间治疗前后差值比较有非常显著性差异(P<0·001)。结论:丹参注射液对慢乙肝肝硬化血栓前状态有很好的治疗作用。

Objective： To investigate the effect of Salvia injection（SI） on prethrombotic state in patients with chronic hepatitis B or liver cirrhosis. Methods： Plasma yon Willebrand＇s factor（vWF） and D-Dimer（D- D） concentration and serum FDP levers were measured in the patients with chronic hepatitis B or liver cirrhosis. According to the standard of prethrombotic state,64patients with prethrombotic state were studied and randomly divided into two groups, 32 in each group. The patients in treated group were treated with SI （for 4 weeks） plus conventional treatmem,and the patients in control group were treated with conventional treatment only. Results： Before treatment,the level of plasma vWF,D-D and serum FDPin treated group and control group were （230.37±78.39） %, （8.20±3. 15）mg/L, （0.73±0. 14）μg/ml and（243.37±79.85） %, （8. 29± 2.89 ） mg/L, （ 0.80 ± 0. 17 ）μg/ml , respectively （ P：〉 0.05 ）. After treatment, the level of plasma vWF, D- D and serum FDPin treated group and control group were （104.41± 50.89）%, （3.89± 1.37）mg/L, （0.41± 0. 15）μg/ml and （241.96±80.86）%, （8.26±2.83）mg/L, （0.79±0. 17）μg/ml ,respectively（P〈0. 001）. The effect of lowering was greater in the treated group than that in the control group （P〈0. 001）. Conclusion： SI has better effect on prethrmbotic state in patients with chronic hepatitis B or liver cirrhosis.