血浆Nt-proBNP测定在早期诊断无ST段抬高急性冠脉综合征的临床意义

Clinical meaning of N-terminal pro-B-type natriuretic peptide in early diagnosing the patients with non-ST-elevation acute coronary syndrome

目的:探讨血浆Nt-proBNP测定在早期诊断无ST段抬高急性冠脉综合征的临床意义。方法:选取55例无ST段抬高急性冠脉综合征患者,分为无ST段抬高心梗组(NSTEMI组,20例)和不稳定心绞痛组(UA组,35例),胸痛症状发作6小时内测定血浆Nt-proBNP水平,和正常对照组(20例)比较。结果:与对照组(191.4±127.3)fmol/l比较,无ST段抬高急性冠脉综合征患者血浆Nt-proBNP水平明显升高(P<0.01),但NSTEMI组(587.3±170.1)fmol/l和UA组(605.4±152.3)fmol/l之间比较差异无显著性(P>0.05)。结论:血浆Nt-proBNP水平测定可对无ST段抬高急性冠脉综合征早期诊断提供非常有价值的参考依据。

Objective： To investigate the clinical meaning of N-terminal pro-B-type natriuretic peptide （Nt-proBNP）in early diagnosing the patients with non-ST-elevation acute coronary syndrome（ACS）. Methods：55 patients with non-ST-elevation ACS were derided into two groups：non-ST- elevation myocardial infarction group（group NSTEMI,20 cases）and unstable angina group （group UA,35 cases）.The plasma levels of Nt-proBNP were measured within six hours after the onset of chest pain and compared with control group of 20 healthy volunteers.Results：Compared with control group（191.4±127.3）fmol/l,the plasma levels of Nt-proBNP were higher in non-ST-elevation ACS patients（P〈0.01） .there was no significant difference between group NSTEMI（587.3±170.1）fmol/l and group UA（605.4±152.3） fmol/l.Conclusion：Nt-proBNP can be used as a diagnostic parameter for early non-ST-elevation ACS.