联合应用降压药物对防治高血压及其并发症的疗效观察

Efficacy of combination of multiple drugs in the management of hypert ension

目的:探讨联合应用血管紧张素转换酶抑制剂和钙通道阻滞剂对防治高血压及其并发症产生的影响。方法:临床选取80例高血压患者,随机分为单独用药组和联合用药组,观察对血压、肝、肾功能、血脂、血糖、肾小球滤过率等的影响。结果:联合用药组用药后降压效果显著,分别与单独用药组相比存在显著性差异,P<0.05。而联合用药对肝肾功能、血脂、血糖等没有产生显著影响,但是可以看出联合用药后血肌酐较用药前有显著改善P<0.05,而且与单独用药组相比,对肾小球滤过率有显著升高的作用,P<0.05。结论:高血压患者以血管紧张素转换酶抑制剂为基础,联合应用钙通道阻滞剂,疗效十分理想。

Objective：To examine a proper treatment for hypertension in the patients with hypertension.Methods：ln this study, 80 patients with hypertension were randomized into three arms of antihypertensive treatment： group A and group B treated with only one drug, group C treated with two drugs.At the same time, testing the levels of GFR, renal function, liver function, glucose, etc.Results： Eight weeks later, both SBP and DBP were decreased significantly in all of the patients （P〈0.05）. The blcod pressure was lower in the patients with two drugs than with only one drug.The renal function of the patients with two drugs grown is better than the patients with only one drug （P〈0.05）.And the level of GFR was increased in the patients with two drugs.Conclusion： Treatment of hypertension by combining ACEI and CCB is superior to the treatment alone, and the treatment can postpone the progression of the organ.