治疗早期帕金森病的临床证据

Evidence of Therapy of Early Parkinson’s Disease

帕金森病是中老年人常见的中枢神经系统退行性疾病,在其早期给予合理的治疗有利于提高患者的生活质量,降低长期用药引起的运动并发症。本文介绍有关早期帕金森病治疗的临床证据,干预措施包括多巴胺受体激动剂,左旋多巴制剂,及多巴胺能神经保护剂等药物及早期步态训练等。

Patients with early Parkinson＇ s disease should be treated rationally in order to improve their quality of life and reduce the motor complications. The early employment of drugs which provides sustained central dopamine agonism and dopaminergic neuroprotection may reach this aim to some extent. Evidence of effective therapy in early Parkinson＇ s disease will be introduced including： dopamine agonists, monoamine oxidase inhibitor 13, coenzymeQ10, L-dopa and a gait training.