中药二至丸对老年痴呆模型小鼠脑组织Na^+-K^+-ATPase、Ca^(2+)-ATPase活性及学习记忆的影响

Effects of Erzhiwan on the Na^+-K^+-ATPase,Ca^(2+)-ATPase Activities and Learning Memory in Mice model of Alzheimer Disease

目的:观察中药二至丸对老年痴呆(alzhe im er d isease AD)模型小鼠脑组织Na+-K+-ATPase、Ca2+-ATPase活性及学习记忆的影响。方法:颈背部皮下注射D-半乳糖建立亚急性老年痴呆模型,测定脑组织中Na+-K+-ATPase、Ca2+-ATPase活性、采用跳台法测定小鼠的学习记忆能力。结果:中药二至丸能明显提高Na+-K+-ATPase、Ca2+-ATPase活性、缩短小鼠学习潜伏期,延长记忆潜伏期、减少错误次数。结论:中药二至丸能改善老年痴呆模型小鼠的学习记忆能力,提高ATP酶的活性,维持脑组织的正常功能。

Objective： To observe the effects of Erzhiwan on the Na^＋-K^＋-ATPase,Ca^2＋-ATPase ase activities and learning memory in mice model of Alzheimer Disease. Methods： The mice were pefformed by neck back hypodermic injection of D-galactose to set up the subacute Alzheimer Disease model, tested for learning memory by the method of diving platform, and determined for the Na^＋-K^＋-ATPase ＆ Ca^2＋-ATPaseactivity in their brain tissues. Results： Erzhiwan could obviously shorten the latency of learning period, prolong the incubation period of memory and reduce the times of mistakas. Conclusion： Erzhiwan can improve the learning memory of Alzheimer Disease mice, raise activation of ATPase and maintain the normal function of the brain tissues.