糖蛋白性肿瘤相关抗原与慢性心力衰竭的关系

The Relationship between Serum Levels of Glycoprotein-tumor associated Antigens and Chronic Heart Failure

目的研究糖蛋白性肿瘤相关抗原甲胎蛋白(AFP)、癌胚抗原(CEA)及癌抗原125(CA125)与慢性心力衰竭(CHF)的关系。方法采用ELISA法测定97例CHF患者血清AFP、CEA及CA125水平,并对20例NY-HAIV级患者治疗前、后血清AFP、CEA及CA125水平进行比较,用心脏彩色多普勒超声心动仪测定左心室功能。结果(1)各组患者血清AFP及CEA值均正常;血清CA125水平随心衰程度的加重而显著升高,与NYHAⅡ、Ⅲ级相比,NYHAⅣ级显著上升(P<0·05),且与左室射血分数(LVEF)呈负相关(r=-0·81,P<0·001)。(2)NYHAIV级患者治疗前、后AFP及CEA均值间差别均无显著性意义(P>0·05),血清CA125均值间差别有显著性意义(P<0·005)。结论血清CA125水平能预测CHF严重程度,较好地反映左室功能状态。

Objective To investigate the relationship between the serum levels of alpha fetoprotein （ AFP）, carcinoembryonic （CEA）, cancer antigen 125 （CA125） and chronic heart failure （CHF）. Methods We measured the serum levels of AFP, CEA and CA 125 by enzyme linked immunosorbent assay （ELISA） in patients with mild to severe CHF （n = 97）, and compared the levels of NYHAⅣ patients （ n = 20） before and after treatment. Colored Doppler echocardiography was performed to measure the left ventricular function. Results （ 1 ） The mean values of AFP and CEA were in the normal range. The serum levels of CA125 increased with increment of NYHA classification （ P 〈 0. 05 ） , which was negatively correlated with left ventricular ejection fraction （ P 〈0. 001 ）. （2） In 20 NYHAⅣ patients after aggressive medical treatment, the mean serum levels of CA125 decreased from 178.5 ± 113.2 to 26. 8 ± 14. 1 UI/ml （ P 〈 0. 005 ）; the change in other tumor- associated antigens wasn＇t observed. Conclusion Among the tumor -associated antigens evaluated, only CA125 seems to be related with the presence and severity of CHF, which shows the significant changes in response to medical therapy.