纤维蛋白胶对乳腺癌术后伤口积液的预防作用研究

The Prevention Effect of Fibrin Sealant on the Subcutaneous Exudation of Mammary Cancer Operation

目的研究纤维蛋白胶对乳腺癌术后伤口积液的预防作用.方法 2000年12月～2002年11月我科行乳腺癌改良根治术患者197例,按使用纤维蛋白胶与否分组.使用组患者79例,未使用组患者118例,使用组于术中应用纤维蛋白胶1支(5 ml/支)喷洒于手术野和腋窝,未使用组仅行常规处理.两组患者术后腋窝均放置血浆管行负压引流和加压包扎伤口,记录术后伤口引流量,于术后5～7 d打开包扎,观察有无腋下和/或皮瓣积液.结果使用组患者发生皮瓣和/或腋窝积液7例(8.86%),未使用组发生伤口和/或腋窝积液23例(19.49%),两组患者积液发生率间差别有显著性意义(P＜0.05).两组引流量间差别也有显著性意义(P＜0.05).结论纤维蛋白胶对乳腺癌术后皮瓣和/或腋窝积液有良好的预防作用.

Objective To study the prevention effect of fibrin sealant on the subcutaneous exudation after mammary cancer operation. Methods 197 cases, who underwent modified radical masteetomy from 12, 2000 to 11, 2002, were divided into the test team and the control team. 79 eases used fibrin sealant and r 118 cases didn＇t. One fibrin sealant was sprinkled at the operation field and axillae of the patients who were included in the test team, then drainage - tube was put and the wound were bandaged through pressure. The draining quantity was measured after the operation. The subcutaneous exudation and exudation of oxter were tested 5 days after the operation. Results The subcutaneous exudation and exudation of oxter were found in 7 cases in the test team, and the incidence rate is 8. 86%. The subcutaneous exudation and exudation of oxter were found in 23 eases in the test team, and the incidence rate is 19.49%. It is obviously different between the two teams. The draining quantity of the test team is evident less than that of the control team. Conclusion The fibrin sealant has better effect on the prevention of the subcutaneous exudation and exudation of oxter after mammary cancer operation.