摘要
目的:研究巴豆生物碱对人胃癌细胞SGC-7901表型逆转作用。方法:测定人胃癌细胞SGC-7901药物处理前后胃蛋白酶原(PG)和β-葡萄糖醛酸酶(β-G)活力,数据采用Scheffe's测试法分析。结果:巴豆生物碱处理能有效逆转人胃癌细胞SGC-7901中胃蛋白酶原活性,且能部分抑制人胃癌细胞SGC-7901中肿瘤标志酶β-葡萄糖醛酸酶的表达。结论:巴豆生物碱对人胃癌细胞SGC-7901表型有逆转作用。在对胃蛋白酶原活性的逆转作用和对β-葡萄糖醛酸酶的表达的抑制作用较维甲酸好。
Objective：Study the phenotype reversion of croton seed alkaloid on human being stomach cancer cell SGC-7901. Method： Test the activity of pepsinogen（PG）and glucose aldehydic acid enzyme（β-G） of human stomach cancer cell SGC-7901 before and after medication,analyze it with Scheffe＇s test method. Result：Croton seed alkaloid can effectively reverse the pepsinogen activity, and partly inhibit the expression of the tumor symbol enzyme-β-G in human stomach cancer cell SGC-7901. Conclusion： Croton seed alkaloid can reverse the phenotype ofhuman stomach caner cell SGC-7901. On the reversion to pepsinogen activity and inhibition to β-G,it is better than vitamin A acid.
出处
《浙江中医学院学报》
2005年第5期64-65,共2页
Journal of Zhejiang College of Traditional Chinese Medicine
基金
江苏省教育厅课题(01KJB360005)
