187例药源性皮肤病回顾性分析

Analysis of 187 Cases with Drug-induced Skin Diseases

目的探讨药源性皮肤病的一般规律和特点,为临床合理用药提供参考. 方法采用回顾性研究的方法,对1996年6月～2004年12月国内医药期刊报道的药源性皮肤病187例,按性别、年龄、药物及给药途径、发生时间、发生部位、康复时间等进行统计分析. 结果药源性皮肤病男性略多于女性,年龄6个月至73岁,发生时间数分钟至数天,主要发生的部位是全身反应, 康复时间数小时至30天. 结论临床医生、药师应了解药源性皮肤病发生的规律和特点,加强监测,以减少药源性皮肤病的发生.

Objective To study the general rule and characteristic of drug-induced skin diseases in order to provide some references for rational drug uses in the clinic. Methods By taking retrospective analysis, we analyzed and evaluated 187 cases drug-induced skin diseases that they were reported by medical journals of Chinese during June 1996 to December 2004 according to the sex, the age, drugs and the route of administration, the time of occurrence, the location, the time of recovery. Results The drug-induced skin diseases are slightly more in men than women. The ages of invasion are 6 month to 73 ages. The times of occurrence are from minutes to days. The main position is skin damage of whole body. The times of recovery are from hours to 30 days. Conclution The clinical doctors and pharmacists should understand the rules and the characteristics of drug-induced skin diseases and strengthen monitoring of their use in order to reduce the occurrence of drug-induced skin diseases.