硫酸茚地那韦的人体药动学

Study on HPLC determination of indinavir sulfate capsules in human plasma and its pharmacokinetics

目的:研究硫酸茚地那韦胶囊在健康受试者中的药动学特征。方法:对10名健康男性受试者接受单次口服800mg硫酸茚地那韦胶囊后的药动学进行了研究。采用HPLC法测定血浆中药物的浓度。结果:经DAS ver1.0药动学计算程序处理拟合,数据符合口服给药一室开放模型,其药动学参数分别为:tmax为(0.55±0.11)h,t1/2a为(1.03±0.19)h,Cmax为(18.4±4.8)mg·L-1,用梯形法计算所得的AUC0-t为(34.9±14.2)mg·L-1·h。结论:为临床用药提供参考资料。

OBJECTIVE To study the pharmacokinetic characters of indinavir sulfate capsules in human plasma. METHODS The plasma concentration of indinavir sulfate was determined by RP-HPLC method following a single oral dose of 800 mg in an open randomized design. RESULTS The main pharmacokinetic parameters of test was as follows, tmax was（0. 55 ± 0. 11）h,t1/2a was （1.03± 0. 19）h,Cmax was（18.4±4. 8）mg.L^-1 ,AUG0-t was（34. 9 ± 14. 2）mg·L^-1·h respectively. CONCLUSION The study provides useful information for clinical trail.