早孕人工流产术前口服和阴道放置米索前列醇的效果

EFFCTS OF MISOPROSTOL ADMINISTRATED ORALLY AND INTRAVAGINALLY ON INDUCED ABORTION IN EARLY PREGNANCIES

①目的探讨早孕人工流产术前应用米索前列醇(米索)的途径。②方法初次妊娠的早孕妇女200例,随机分成口服米索组(A组)与阴道放置米索组(B组),各100例。A组术前2h口服米索400μg,B组术前2h将米索400μg放入阴道后穹隆,两组均于用药2h后行人工流产术。观察并比较两组不良反应发生率、宫颈软化、宫颈扩张情况及人工流产综合反应发生情况。③结果B组不良反应发生率低于A组,差异有显著性(χ2=4.52～37.52,P<0.05、0.01);两组宫颈软化及宫颈扩张情况无显著性差异(P>0.05);A组出现轻度人工流产综合反应者30例(30%),中度反应5例(5%);B组出现轻度人工流产综合反应者29例(29%),中度者3例(3%),两组比较差异无显著性(P>0.05)。④结论阴道放置米索可作为人工流产术前扩张宫颈的理想给药方法。

Objective To study the way of using Misoprostol before induced abortion in early pregnancy. Methods Two hundred women with early pregnancy were randomly divided into two groups： group A and group B. Misoprostol （400μg） was administrated orally and intravaginally two hours before the procedure in group A and B, respectively. The side effects of Misoprostol, the cervical dilatation and softening and induced abortion syndrome were observed. Results The side effects in group B was fewer than in group A （χ^2 = 4.52-37.52;P〈0.05,0.01）. The differences between the two groups were not significant in terms of dilatation and softening of the cervix （P〈0.05）. As for induced-abortion syndrome, mild symptoms were found in 30 cases （30%）, and moderate,5 （5%） in group A; and mild, 29, moderate, 3, in group B. The difference was not significant （P〉0. 05）. Conclusion Misoprostol administrated intravaginally is an ideal approach for dilation of he cervix before induced abortion in early pregnancy.