急性心肌梗死病人CRP及CK-MB测定及其意义

THE LEVELS OF CRP AND CK-MB AND THEIR SIGNIFICANCE IN PERIPHERAL BLOOD OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

①目的探讨急性心肌梗死病人外周血中C反应蛋白(CRP)和肌酸激酶同工酶(CKMB)含量变化与冠心病病理变化过程、病情进展和转归的关系。②方法对40例急性心肌梗死病人发病后不同时间和冠状动脉支架安置术后6h外周血中CRP和CKMB含量分别进行检测并与正常对照组进行比较。③结果急性心肌梗死病人发病6～14h血清中CRP和CKMB含量明显升高,与对照组比较差异有显著性(t=2.065～2.740,P<0.05)。冠状动脉支架安置术后外周血中CRP和CKMB含量与急性心肌梗死发病后14h相比明显减低,差异有显著性(t=2.031、2.368,P<0.05)。④结论急性心肌梗死发病后6h外周血中CRP和CKMB含量即开始升高,在14h明显升高。随着治疗的干预,临床症状得到缓解,受损心肌逐渐康复,外周血中CRP和CKMB的含量逐渐下降。因此,CRP及CKMB含量的测定对于预测急性心肌梗死病人病情及预后有一定价值。

Objective To determine the levels of CRP and CK-MB in peripheral blood in patients with acute myocardial infarction （AMI）, and to analyze the relationship between CRP and CK-MB and the pathologic changes and improvement of the disease. Methods This study included 40 patients with AMI and those six hours after coronary stenting. The concentrations of CRP and CK-MB were determined at different times and compared with that of the normal controls, Results The CRP and CK-MB were higher in the patients after 6 14 hours than those of the control group （t=2.065-2.740, P〈0.05） . There was a significant difference between the reduction in CRP and CK-MB levels after coronary stent implantation and 14 hours after AMI onset （t=2. 031, 2.368; P〈0.05）. Conclusion The levels of CRP and CK-MB increased at six hours after onset of the disease, and greatly increased after 14 hours. CRP and CK-MB levels were depressed and clinical symptoms relieved after the therapy. The detection of CRP and CK-MB is helpful in the judgement of the prognosis of AMI .