深部真菌感染24例临床分析

The Clinical Analysis of 24 Patients with Deep Fungal Infection

目的:探讨深部真菌感染的发病特点和防治策略。方法:回顾性分析24例深部真菌感染患者的临床资料。结果:24例患者共检出真菌64株,其中白色念珠菌最多,占53%,合并细菌感染75%,深部真菌感染前用过广谱抗生素者占88%。结论:深部真菌感染在使用强效、广谱抗生素患者中发病率高,治疗上常用氟康唑,两性霉素B脂质体,疗效好、副作用小。

Objective： To explore the clinical characteristics, prevention and treatment of deep fungal infection （DFI）. Methods： Clinical retrospective study of 24 consecutive patients with DFI. Results： 24 patients were checked with 64 fungal strains. Candida was the most pathogenic organism （53%）. There were 75% of patient infected with bacterium. 88% of patient were used broad-spectrum antibiotic. Conclusions： The incidence rate of DFI in patient used powerful broad-spectrum antibiotic was high. Flueonazole and amphoteriein liposome had good curative effect with little side effect in the treatment of DFI.