利用体内^（19）FNMR研究5─氟尿嘧啶在小鼠肝脏及肿瘤组织中的代谢过程

IN VIVO ￣(19)F NMR STUDY ON METABOLISM OF 5-FLUOROURACIL IN MURINE LIVER AND IMPLANTED TUMOR

利用体内１９ＦＮＭＲ研究了５─氟尿嘧啶在小鼠肝脏及植入肿瘤组织中的代谢过程．５─氟尿嘧啶在肝脏中的生物半衰期为１５～２０ｍｉｎ，而在Ｓ１８０肿瘤中的生物半衰期为５０─６０ｍｉｎ．除５─氟尿嘧啶的信号外．在肝脏中观测到了５─氟尿嘧啶的分解代谢产物ＦＵＰＡ和ＦＢＡＬ，而在肿瘤中则只有合成代谢产物氟代核苷酸的信号．实验结果表明．核磁共振是研究药物在体内代谢过程的有力方法．

Metabolism of 5-fluorouracil(5FU) in mouse liver and implanted S180 tumor was studied using in vivo 19F NMR spectroscopy. The half-life of 5FU elimination is about 15-20min in liver and 50-60min in tumor.Catabolites of 5FU,fluorouredopropanic acid and α-fluoro-β-analine,were observed in livel, while only the fluoronucleotides,anabolites of 5FU,were observed in tumor. The results show that NMR spectroscopy is a powerful method for metabolic and pharmacokinetic studies.