摘要
目的:观察不同浓度含碘中药对甲亢大鼠模型甲状腺组织bcl-2、baxmRNA表达的影响。方法:制作大鼠甲状腺机能亢进模型,灌服不同浓度含碘中药复方及其他对照药物进行治疗,然后RT-PCR法检测各组大鼠甲状腺组织bcl-2、baxmRNA水平。结果:含碘较低的中药复方较之含碘高的中药复方在增加bcl-2mRNA表达及减少baxmRNA表达上具有显著性的差异。结论:小剂量含碘中药复方对实验性甲亢大鼠甲状腺细胞具有保护作用。
Objective：To study the effects of Chinese mdicinal containing different concentration of iodine（Ⅰ）on the gene expression of bcl- 2 and bax on the model of hiperthyreosis in rats. Methods ： After the model of hiperthyreosis were made, each group of rats was treated with Chinese medicinal containing different concentration of iodine and other drugs separately. And then the gene expression of bcl - 2 and bax were analysed by RT - PCR. Results ：The difference of the expression of bcl - 2 and bax between the Chinese medicinal containing lower concentration iodine and higher concentration iodine was significant（ P 〈 0.01 ）. Conclution ：The Chinese medicinal containing lower concentration iodine could protect thyroid gland cells of the model of hiperthyreosis in rats.
出处
《中医药学刊》
2005年第9期1600-1601,共2页
Study Journal of Traditional Chinese Medicine
基金
广东省中医管理局课题(粤中医〔2001〕14号)
