代谢综合征患者肱动脉血管顺应性的超声研究

The value of the humeral vascular compliance in patients with metabolic syndrome

目的:探讨代谢综合征(MS)患者肱动脉血管顺应性的改变。方法:选择MS患者38例为研究组(MS组)、健康查体者35例为对照组(NC组),采用彩色多普勒超声诊断仪检测肱动脉在静息、反应性充血和舌下含服硝酸甘油后血管舒张末期内径的变化。结果:MS组的内皮依赖性血流介导的舒张功能(FMD)及非内皮依赖性硝酸甘油介导的舒张功能(NID)明显低于对照组(P<0.05),FMD与年龄、体重指数、三酰甘油、收缩压、舒张压、血糖呈负相关。结论:代谢综合征患者存在较严重的血管顺应性减低及血管内皮功能失调,FMD及NID的测定对MS动脉粥样硬化的预测和防治具有重要意义。

Objective：To evaluate the value of humeral vascular compliance in patients with metabolic syndrome（MS）. Methods： Thirty-eight patients suffering from MS （Group MS）and 35 healthy people （Group NC） were employed to measure the baseline inner diameter of humeral artery, artery diameters after reactive hyperemia and nitroglycerin sublingual respectively by the high resolution ultrasound technique. Resuits： The value of endothelium-dependent blood flow mediated vasodilation （FMD） and non-endotheliumdependent nitroglycerin induced vasodilation （NID） in group MS were lower significantly than those in group NC （ P 〈0.05 or P 〈0.01 ）. FMD in the group was significantly negatively related with age, BMI, TG, SBP, DBP and FBG respectively. Conclusion： The patients with MS showed severe dysfunction on vascular endothelial function and vascular compliance. The determinations on FMD and NID have great significance on predicting and preventing atherosclerosis.