MTRR A66G、MSD919G、MTHFR C677T基因多态性与脑梗死的关系

The relationship between gene polymorphisms of MTRR A66G, MS D919G, MTHFR C677T and cerebral infarction

目的探讨MTRRA66G、MSD919G、MTHFRC677T基因多态性与脑梗死的关系。方法选择136例脑梗死(CI)患者和70例对照,用PCR-RFLP方法分析其MTRR、MS和MTHFR基因型。结果CI组和对照组的MTRRA66G多态性的分布差异无显著性意义(χ2=1.645,P=0.439);CI组与对照组相比,MSD919G各基因型的频率差异无显著性意义(χ2=1.040,P=0.595);两组的MTHFRC677T各基因型的频率差异也没有显著性意义(χ2=1.399,P=0.497)。结论通过实验推测MTRRA66G、MSD919G、MTHFRC677T基因多态性不是CI的独立遗传危险因素。

Objectives To analyze the relationship between gene polymorphisms of MTRR A66G, MS D919G, MTHFR C677T and cerebral infarction （CI）. Methods 136 CI patients confirmed by cranial CT or MRI were involved into the study and 70 subjects without stroke into control group. Gene polymorphisms ofMTRR A66G, MS D919G, MTHFR C677T were detected by PCR-RFLP technique. Results There was no statistically significant difference in the distribution of the MTRR genotypes between CI and controls （X^2=1.645 ,P〉0.05）. No difference was found in the gene frequency of the MS genotypes between CI and controls （X^2=1.040 ,P〉0.05）. There was no difference in the gene frequency of MTHFR genotypes between CI and controls （X^2=1.399 ,P〉0.05）. Conclusions Gene polymorphisms of MTRR A66G, MS D919G, MTHFR C677T may not be independent genetical risk factors of CI.