期刊文献+

病毒载体研究进展 被引量:1

Progress on the Virus-Vector
下载PDF
导出
摘要 外源基因进入细胞通常需要“运载工具”。在漫长的自然进化过程中,病毒是以寄生形式存活下来的最小、最简单的生命体,病毒分子生物学的发展为生物工程领域研究拓展了思路,提供了有效的方法和工具。重组病毒载体又是当今病毒基因工程研究的热点之一,目前以动物病毒为基础设计的基因克隆及表达载体主要有取代型的重组病毒载体和重组的病毒-质粒载体。文章对应用较广泛的病毒载体做一综述。 With the development of bio-molecule and bio-technique, virus were used to study virus vector. At present, recombinant virus vector is one of the most hotspots in virus gene engineering, There are two vector type, the replaceable recombinant virus vector and the recombinant viral plasmid vector. This paper viewed common virus vector to afford a new method for empoldered new vaccine and foreign gene expression
出处 《动物医学进展》 CSCD 2005年第9期4-7,共4页 Progress In Veterinary Medicine
基金 国家863高技术研究发展计划(2003AA241110)
关键词 病毒栽体 重组病毒栽体 病毒质粒 栽体 virus vector recombinant virus vector recombinant viral plasmid vector
  • 相关文献

参考文献15

  • 1http://www.scitom.com.cn/discovery/virus/vir30102.html.
  • 2Mcabe B J,Irvine K R,Nishimura M I,et al.Minimal determinant expressed by a recombinant vaccinia virus elicits therapeutic antitumor cytolytic T lymphocyte responses[J].Cancer Res, 1995,55(8):1741-1747.
  • 3Wu X, Li Y,Crise B, et al. Transcription start regions in the human genome are favored targets for MLV integration[J]. Science,2003,300(56):1749-1751.
  • 4舒俭德.新疫苗临床考察及使用.中国计划免疫,2000,(4):22-26.
  • 5Miller R H, Pucell R H. Hepatitis C virus shares amino acid sequence similarity with pestivirus and flavivirus as well as members of two plant virus supergroups[J]. Proc Nat Acad Sci USA, 1990,87:2057-2063.
  • 6Koshy R, Inchauspe G,Batey R G,et al. Evalution of hepatitis C virus protein epitopes for vaccine development[J]. Trends Bio Technol, 1996,14:364-369.
  • 7.[EB/OL].http://www.bufotanine.com/genedatabase/contents/1038377366.html,.
  • 8Bruder J T, Appiah A, Kirkman W M,et al. Improved production of adenovirus vectors expressing apoptotic transgenes[J]. Hum Gene Ther, 2000,(11):139-149.
  • 9Mohr L, Shankara S, Tanoue T,et al.Gene therapy of hepatocellular carcinoma in vitro and in vivo in nude mice by adenoviral transfer of the Escherichia coli purine nucleoside phosphorylase gene[J]. Hepatology, 2000,31:606-614.
  • 10Bramson J L, Hitt M, Addison C L, et al. Direct intratumoral injection of an adenovirus expressing interleukin-12 induces regression and long-lasting immunity that is associated with highly localized expression of interleukin-12[J]. Hum Gene Ther, 1996,(7):1995-2002.

同被引文献7

  • 1侯云德.分子病毒学[M].北京:学苑出版社,1996,114-150.
  • 2Baskerville A. The influence of dose of virus on the clinical signs in experimental Aujeszky's disease in pigs[J]. Br Vet, 2005, 128: 394-401.
  • 3BrownTT. Laboratory evaluation of selected disinfectants as vinwi dal agents against porcine parvovirus, pseudorabies virus and trans missible gastroenteritis virus. Am.[ J].Vex Res. 2003, 42: 1033- 1036.
  • 4Davies E Bet al . Influence of environmental factors upon the survival of Aujeszky's disease virus .Res [J]. Vet Sci., 31:32.-36
  • 5Davison A J,et al. The complete DNA sequence of vaficella-zoster virus.[ J]. Gen. 2006,1759-1816.
  • 6Feildmann L, et al. Transcription of the genome of pseudorabies virus (A Ilerpesvirus) is strictly controlled.[J].Vet,2004: 316-327.
  • 7肖少波,陈焕春,方六荣,王革飞,马相如.伪狂犬病病毒Ea株gM和gN基因的克隆与结构分析[J].中国预防兽医学报,2002,24(3):171-174. 被引量:2

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部