摘要
目的是研究力学因素和生物学因素在松质骨骨质疏松过程中的作用。根据骨重建的生理过程,在基本多细胞单位(BMUs)层次建立了一个力学因素和生物学因素耦联的,带有时间历程的松质骨骨质疏松过程计算模型。通过调整模型中的力学因素和生物学因素,模拟了妇女绝经期骨量变化过程,其模拟结果与Recker等[1]临床观测结果非常接近。可见,本研究提出的松质骨骨质疏松过程计算模型可以很好地描述松质骨的骨质疏松过程,为中老年群体防治骨质疏松提供理论基础和计算分析方法。
The aim of this paper was to investigate the contributions of mechanical factor and biological factor to the osteoporotic process of cancellous bone. Based on the physiology of bone remodeling, a mechanical-biological factor coupled computational model at Basic Muhicellular Units （BMUs） level was put forward, which can describe the osteoporotic process of cancellous bond with time course. By adjusting the parameters in the model representative of mechanical factor and biological factor respectively, the bone loss patterns of menopausal women were simulated. The results were consistent with the clinical data presented in the literature（Recker et al. ）.The computational model put forward in this paper is capable of describing the osteoporotic process in cancellous bone. Furthermore, it can provide theoretical basis and computational method for the treatment and prevention of osteoporosis.
出处
《中国生物医学工程学报》
EI
CAS
CSCD
北大核心
2005年第4期385-390,396,共7页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(10372034)
教育部博士点基金资助项目(20020183026)。
关键词
松质骨
骨质疏松
计算模型
力学因素
生物学因素
Cancellous bone
Osteoporosis
Computational model
Mechanical factor
Biological factor
