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恶性淋巴瘤组织中内皮细胞特异性分子-1 mRNA及其蛋白的表达 被引量:1

Effect of endothelial cell specific molecule-1 mRNA and protein in malignant lymphoma
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摘要 目的探讨恶性淋巴瘤组织中内皮细胞特异性分子-1(ESM-1)mRNA和蛋白的表达及其与临床病理特征的关系。方法采用免疫组化S-P法、原位杂交方法对58例淋巴瘤组织和10例正常淋巴结的ESM-1蛋白及mRNA进行检测。结果ESM-1蛋白及mRNA在淋巴瘤组织中均有表达,在血管中较少表达。结论ESM-1分子可能参与了淋巴瘤的发生发展过程。 Objective To explore the effect of endothelial cell-specific moelecule-1 ( ESM-1 ) mRNA and protein in malignant lymphoma. Methods Immunohistochemistry detection (S-P method ) and in situ hybridization method were used to detect the expression of ESM-1 protein and mRNA in 58 cases of lymphoma and 10 cases of normal lymph node. Results The expression of mRNA and protein was found in lymphoma but less in vascular endotheliurn. Conclusion ESM-1 might be involved in the development of lymphoma.
出处 《安徽医科大学学报》 CAS 北大核心 2005年第5期402-404,共3页 Acta Universitatis Medicinalis Anhui
基金 国家自然科学基金(编号:39870324) 安徽省人事厅跨世纪学术带头人研究基金 安徽省自然科学基金(编号99044312) 安徽省教育厅自然科学基金(编号2003kj184)资助项目
关键词 淋巴瘤 免疫组织化学 原位杂交 lymphoma immunohistochemistry in situ hybridization
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参考文献7

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同被引文献6

  • 1徐大林,桂淑玉,李永怀,谢斌,周青,丁向东,汪渊.内皮细胞特异性分子-1在肺癌组织中的表达及其临床意义[J].安徽医科大学学报,2007,42(4):363-367. 被引量:4
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  • 6熊江霞,吴强,周青,吴正升,桂淑玉,汪渊.肾癌组织中内皮细胞特异性分子-1 mRNA水平及其蛋白表达的关系[J].临床与实验病理学杂志,2004,20(2):187-190. 被引量:4

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