p34cdc2在舌鳞癌中的表达及意义

The expression and significance of p34cdc2 in tongue squamous cell carcinoma

目的研究舌鳞癌组织中p34cdc2的表达,探讨其表达与舌鳞癌临床病理特征的关系。方法随机收集舌鳞癌(含正常舌组织或癌旁组织)标本60例,采用免疫组织化学S-P法显示p34cdc2蛋白的表达,并结合舌鳞癌的临床病理特征进行分析。结果舌癌组织中可见p34cdc2蛋白表达并显棕色,主要定位于细胞浆中,正常/癌旁上皮组织中少见p34cdc2蛋白表达。p34cdc2在癌组织中存在过表达,与正常组织或癌旁组织中p34cdc2蛋白的表达有显著性差异(P<0.01)。结论p34cdc2蛋白在舌鳞癌中有过表达现象,可反映舌鳞癌细胞分裂增殖能力;过表达的p34cdc2蛋白可作为评价舌鳞癌临床分期和组织分级等临床病理特征的参考指标之一。

Objective To study the expression of p34cdc2 protein in tongue squamous cell carcinoma （ SCC ） and the relationship between the expression of p34cdc2 protein and the clinicopathological features of tongue SCC. Methods 60 cases of tongue SCC with healthy tongue tissues or neighboring noncancerous tissues were selected randomly. These samples were detected by immunohistochemiscal method, and the clinicopathological features of tongue SCC were analyzed. Results The expression of p34cdc2 was localized in cytoplasm of tongue SCC cells, showing brown. The difference was statistically significant between the expression of p34cdc2 in cancer tissues and healthy or neighboring non-cancerous tissues （ P 〈 0. 01 ）. Conclusion Over-expression of p34cdc2 is found in tongue SCC. Over expression of p34cdc2 can be one of good marks in showing the proliferative ability of tongue SCC and determining the clinical stages, histological grades and other clinicopathological features of tongue SCC.