丽珠得乐治疗消化性溃疡的疗效观察

Effects of Bismuth Potassium Citrate Granules on Peptic Ulcers

目的:探讨丽珠得乐治疗消化性溃疡的临床疗效。方法:将62例消化性溃疡患者随机分为两组:观察组33例和对照组29例。观察组采用丽珠得乐220mg,口服,2次/d,阿莫西林500mg,口服,2次/d,呋喃唑酮100mg,口服,2次/d,雷尼替丁150mg,口服,2次/d,疗程为2周;对照组采用硫糖铝1000mg,口服,3次/d,阿莫西林500mg,口服,2次/d,呋喃唑酮100mg,口服,2次/d,雷尼替丁150mg,口服,2次/d,疗程为2周。观察两组疗程结束后1周和2周时主要症状的消失率及疗程结束后2周时复查胃镜示溃疡愈合情况。结果:观察组疗程结束后1周时腹痛消失率、反酸消失率分别为62.5%、63.3%高于对照组的50.0%、53.8%(P均<0.05);观察组疗程结束后2周时腹痛消失率、反酸消失率、胃镜复查溃疡愈合总有效率分别为87.5%、86.7%、75.7%明显高于对照组的67.8%、69.2%、55.2%(P均<0.05)。结论:丽珠得乐作为胃粘膜保护剂治疗消化性溃疡效果优于硫糖铝。

Objective：To observe the effectiveness of bismuth potassium citrate granules treatment for peptic ulcers. Methods：Sixty-two patients with peptic ulcer were randomly divided into two groups： observation group （n = 33 ） [ gastric ulcer （ n = 7 ） and duodenal ulcer （ n = 26 ） ] were treated with bismuth potassium citrate granules 220 g bid＋Amoxicillin 500 mg bid＋furazolidone 100 mg bid ＋ ranitidine 150 mg bid for two weeks. The control group （n = 29） [gastric ulcer（n= 6） and duodenal ulcer（n=23）]were treated with sucralfate tablets 1000 mg tid＋Amoxicillin 500 mg bid＋ furazolidone 100 mg bid＋ ranitidine 150 mg bid for two weeks. The disappearance rates of the main symptom were detected at one week and two weeks after treatment and re-astroscopy was performed at two weeks after treatment. Results： The disappearance rates of abdominal pain and brash in the observation group （62.5% and63.3%）were higher than those in the control group （50.0%and53.8 %）（P〈0.05, respectively）at one week after treatment. At two weeks after treatment, the disappearance rates of abdominal pain and brash and the total effective healing rate of ulcer in the observation group （87.5%,86.7%and75.7%） were significantly higher than those in the control group（67.8%,69.2%and55.2%）（P〈0.05, respectively）. Conclusion：As a gastricmucosa-protection agent, the effectiveness of bismuth potassium citrate granules treatment for peptic ulcer is more effective than sucralfate.