柚皮苷和新橙皮苷抗过敏作用的研究

Study on the anti-allergic activities of narigin and neohesperidin

[目的]为了研究柚皮苷和橙皮苷的抗过敏作用.[方法]采用DNFB法诱导小鼠3相皮肤炎后,第2～8d连续口服给以柚皮苷和橙皮苷.观察即时相(IPR)、迟发相(LPR)和超迟发相(vLPR)的抑制率.[结果]柚皮苷在投药量为20mg/kg时,对IPR、vLPR的耳缘浮肿产生有效的抑制,抑制率分别为28.2%,26.1%;投药量为100mg/kg,对浮肿各相都产生有效的抑制,抑制率分别为31.7%,25.1%,29.9%.新橙皮苷在20和100mg/kg投药量下,对vLPR相产生有效的抑制,抑制率分别为19.1%,23.6%.[结论]柚皮苷和橙皮苷表现出较好的抑制3相皮肤炎作用,在抗过敏方面具有一定的开发价值.

[ Objective] To study the anti-allergic activities of naringin and neohesperidin. [ Methods] The animal model was established by DNFB method and naringin and neohesperidin were orally administrated from the 2nd to the 8th day. The inhibitory effect to IPR,LPR and vLPR were observed and the inhibitory rates were analysed. [ Results] Naringin inhibited the ear edge swelling of IPR and vLPR at the dosage of 20 mg/kg and the ingibitory rates were 28.2% and 26.1% ; at dosage 100 mg/kg it have the inhibitory effect on all the 3 phases and the inhibitory rates were 21.6（ 1.3% , 21.0（ 1.4% and 27.0（ 1.5% respectively. Neohesperidin showed effective inhibition on vLPR phase at both 20 and 100 mg/kg dosage and the inhibitory rates were 19.1% and 23.6% respectively. [ Conclusion] Naringin and neohesperidin showed better activities against 3 phase dermatomyositis, which suggests these two compounds are valuable in the treatment of allergic.